RESEARCH PROJECTS
MSC Modulate Neurogeneis and Behavior
Mesenchymal Stem Cells (MSC) administration increase hippocampal neurogenesis and improve cognitive and affective behavior in various disease models.
Selected publications:
Transplantation of mesenchymal stem cells reverses behavioral deficits and impaired neurogenesis caused by prenatal exposure to valproic acid
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Immune Regulation of Neurogenesis
The immune system regulate hippocampal neurogenesis. Immune cells and their secreted cytokines and chemokines can promote or inhibit neurogenesis and affect behavior.
Modulation of the immune system by MSC administration, age and gut microbiome can thus affect neurogensis via immune-modulation.
Selected publications:
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Interleukine-17 modulates neurogenesis and behavior following exposure to trauma in mice
MSC-derived Exosomes
Mesenchymal stem cell derived exosomes carry the therapeutic properties of MSC and can modulate hippocampal neurogenesis and its related behavior.
Epigenetic Regulation of Neurogenesis in ASD
Environmental factors are major contributors to neurodevelopmental disorders. Epigenetic modifications are a plausible mechanism for the environmental etiology of autism spectrum disorder (ASD). Epigenetic modulators can thus be a applied for treating ASD.
Selected publication: